What is MIATA?

Analysis of antigen-specific T cell responses has become a widely used tool in immune monitoring. Although an increasing number of promising data from correlative studies has been published and the variables of assay conduct which affect the quality of results have been diligently defined, a lack of conformity in reporting results from T cell assays exists which  hampers the ability to objectively evaluate data.  Here we present a reporting framework that enables an objective and thorough interpretation of published results from T cell assays: “MIATA (Minimal Information About T cell Assays).  MIATA summarizes in 5 modules the essential information to be included in the Materials and Methods section of publications to provide the transparency sought by peers and reviewers, as defined in a 3 year public consultation process.  This website provides the information about how to easily implement MIATA, including I. the MIATA guidelines, II. a checklist that can be executed online, III. example reports, IV. Pre-established editable Materials and Method documents with fill-in options to assist in MIATA-compliant reporting, and V. tools assisting with donor information and term definition MIATA-compliant papers are listed in the MIATA “Hall of Fame” with links to the original article, providing enhanced visibility of the published work. 

MIATA does not impose the use of any standardized protocol or specific reagents nor does it encourage or discourage any specific grade of assay validation. MIATA concentrates on defining the content and structure of information reported from immunoassays. This MIATA website is the official, yet independent tool to provide knowledge about the MIATA reporting framework and its implementation, and the available MIATA-compliant publications. The final MIATA guidelines are published in Immunity and can be found in detailed description here.

What is miata-v2